Matthew Henry's book outlines for the Christian a method of prayer based on adoration, confession of sin, petition and supplication, thanksgivings for mercies, and intercession and supplication for others (ACTS). Henry gives substantial coverage to each of these areas. First, he speaks to the reader about the importance of each area. Then he breaks down each area into its components for specific prayer. For example, under adoration there are fifteen components which Henry addresses including adoring God as the transcendent Being, as creator of the world, as existing in three persons, and as having dominion over us. Henry then takes the reader through each component and offers prayer that is completely generated from the scriptures.

In addition to the method of prayer that Henry outlines for us, editor Duncan included some goodies of his own. In part II of the book, there are three sermons by Henry on daily communion with God: how to begin every day with God, how to spend every day with God, and how to close every day with God. There are also three appendices in this book: an outline for scriptural prayer based on Henry's method of prayer, a pocket outline of the same, and a section on principles for public prayer.